Dmrt3^tm1.1Zark
Targeted Allele Detail

Summary

• Symbol: Dmrt3^tm1.1Zark
• Name: doublesex and mab-3 related transcription factor 3; targeted mutation 1.1, David Zarkower
• MGI ID: MGI:6471086
• Gene: Dmrt3 Location: Chr19:25587665-25601285 bp, + strand Genetic Position: Chr19, 20.5 cM
• Alliance: Dmrt3^tm1.1Zark page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254118
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: The targeting construct is designed to replace exon 1 with a loxP-flanked neomycin cassette. Exon 1 includes the DM domain, a zinc finger-like DNA-binding motif, as well as the transcription start site. Cre-mediated recombination removed the floxed neo cassette. (J:254118)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dmrt3 Mutation: 13 strains or lines available

References

• Original: J:254118 De Clercq S, et al., DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation. Cereb Cortex. 2018 Feb 1;28(2):493-509
• All: 3 reference(s)