Lep^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lep^em1Gpt
• Name: leptin; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6471028
• Synonyms: Lep^-, Lep^em1Cd25
• Gene: Lep Location: Chr6:29060220-29073875 bp, + strand Genetic Position: Chr6, 12.3 cM
• Alliance: Lep^em1Gpt page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology was used to create a 25 bp deletion in the coding region. (J:296618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lep Mutation: 19 strains or lines available

References

• Original: J:296618 Liu L, et al., Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance. Cell Metab. 2020 Oct 6;32(4):605-618.e7
• All: 10 reference(s)