Gt(ROSA)26Sor^{tm1(NDI1)Ncdl}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(NDI1)Ncdl}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Navdeep S Chandel
• MGI ID: MGI:6470933
• Synonyms: NDI1-LSL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(NDI1)Ncdl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The following elements were inserted into intron 1: a CAG promoter, a loxP site, a neomycin resistance gene cassette, a STOP cassette, a second loxP site, the S. cerevisiae NDI1 gene, an FRT site, an IRES, the EGFP fluorescent marker gene, a second FRT site, the WPRE enhancer and poly(A) signal sequences. This allele will express the inserted gene only after cre-mediated removal of the STOP cassette. (J:296588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1205 strains or lines available

References

• Original: J:296588 McElroy GS, et al., NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction. Cell Metab. 2020 Aug 4;32(2):301-308.e6
• All: 7 reference(s)