Del(5Rr78-Rr77)3Tshir
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(5Rr78-Rr77)3Tshir
• Name: deletion, Chr 5, Toshihiko Shiroishi 3
• MGI ID: MGI:6470876
• Synonyms: 9530036O11Rik^em3Tshir, Del(5)2Tshir, deltaFC, Rr(FC)^em3Tshir
• Gene: Del(5Rr78-Rr77)3Tshir Location: unknown Genetic Position: Chr5, Syntenic

Mutation origin

• Strain of Origin: C57BL/6JJcl

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Del(5Rr78-Rr77)3Tshir involves 4 genes/genome features (Rr115, Rr77, Rr78 ...) View all
• CRISPR-targeting deleted 120 kb encompassing Shh brain enhancers 2, 3, 4 and 7 (SBE2-SBE4 and SBE7). (J:282343)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(5Rr78-Rr77)3Tshir Mutation: 0 strains or lines available

References

• Original: J:282343 Sagai T, et al., SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23636-23642
• All: 1 reference(s)