Tg(Mnx1-EGFP)#Chvv
Transgene Detail

Summary

• Symbol: Tg(Mnx1-EGFP)#Chvv
• Name: transgene insertion, Christine Vande Velde
• MGI ID: MGI:6470674
• Synonyms: Endo-MitoEGFP
• Transgene: Tg(Mnx1-EGFP)#Chvv Location: unknown
• Alliance: Tg(Mnx1-EGFP)#Chvv page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene comprises the mouse motor neuron and pancreas homeobox 1 promoter driving the expression of a cytochrome c oxidase subunit VIII mitochondrial targeting sequence-EGFP fusion protein gene. After random genomic integration transgene mRNA is expressed at high levels in vascular endothelium in brain, spinal chord and heart, with lower expression in gastrocnemius muscle, kidney, spleen and lung, and largely absent in liver. Evaluation of EGFP protein levels showed the highest levels detected in the brain, spinal cord, spleen, lymph nodes, thymus and skin, with modest expression in muscle, heart, lung, and intestine, and largely absent in liver and kidney. (J:205933)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:205933 Pickles S, et al., Endo-MitoEGFP mice: a novel transgenic mouse with fluorescently marked mitochondria in microvascular endothelial cells. PLoS One. 2013;8(9):e74603
• All: 2 reference(s)