Gt(ROSA)26Sor^tm1Hrr
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Hrr
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hans-Reimer Rodewald
• MGI ID: MGI:6470644
• Synonyms: Gt(ROSA)26Sor(tm1(Polylox)Hrr), Rosa26^Polylox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Hrr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263633
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus a neomycin resistance cassette and a series of 20 reporter genes interspersed with ten loxP sites in alternating orientation spaced 178 bp apart. The intervening nine DNA blocks are composed of unique sequences based on the AT2G21770 gene from Arabidopsis thaliana. Recombination produces a cell-specific barcode of reporter gene expression. (J:263633)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:263633 Pei W, et al., Polylox barcoding reveals haematopoietic stem cell fates realized in vivo. Nature. 2017 Aug 24;548(7668):456-460
• All: 1 reference(s)