Pycr2tm1.1Brre
Targeted Allele Detail
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Symbol: |
Pycr2tm1.1Brre |
Name: |
pyrroline-5-carboxylate reductase family, member 2; targeted mutation 1.1, Bruno Reversade |
MGI ID: |
MGI:6470408 |
Gene: |
Pycr2 Location: Chr1:180731858-180735653 bp, + strand Genetic Position: Chr1, 84.46 cM, cytoband H5
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Alliance: |
Pycr2tm1.1Brre page
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Germline Transmission: |
Earliest citation of germline transmission:
J:296329
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 3-6 were replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. Western blot and immunofluorescence studies of primary dermal fibroblasts confirmed the lack of protein expression from this allele.
(J:296329)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pycr2 Mutation: |
21 strains or lines available
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Original: |
J:296329 Escande-Beillard N, et al., Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2. Neuron. 2020 Jul 8;107(1):82-94.e6 |
All: |
1 reference(s) |
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