Sst^{tm1.1(rtTA)Mgn}
Targeted Allele Detail

Summary

• Symbol: Sst^{tm1.1(rtTA)Mgn}
• Name: somatostatin; targeted mutation 1.1, Mark A Magnuson
• MGI ID: MGI:6469954
• Synonyms: Sst^rtTA
• Gene: Sst Location: Chr16:23708323-23709708 bp, - strand Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
• Alliance: Sst^{tm1.1(rtTA)Mgn} page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:268101
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a reverse tetracycline TransActivator (rtTA) flanked by Lox66 and Lox2272 along with an FRT-flanked puromycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:268101)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sst Mutation: 38 strains or lines available

References

• Original: J:268101 Cigliola V, et al., Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon(+) alpha-cells. Nat Cell Biol. 2018 Nov;20(11):1267-1277
• All: 3 reference(s)