Nono^em2Yuz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nono^em2Yuz
• Name: non-POU-domain-containing, octamer binding protein; endonuclease-mediated mutation 2, Yun Zhang
• MGI ID: MGI:6469919
• Gene: Nono Location: ChrX:100473295-100492193 bp, + strand Genetic Position: ChrX, 44.14 cM
• Alliance: Nono^em2Yuz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology was used to create a 6 bp deletion (TATCAC)/7 bp insertion (GGGGAAA). (J:294120)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nono Mutation: 32 strains or lines available

References

• Original: J:294120 Xu X, et al., Deficiency of NONO is associated with impaired cardiac function and fibrosis in mice. J Mol Cell Cardiol. 2019 Dec;137:46-58
• All: 2 reference(s)