Tg(CD2-Tcra,-Tcrb)27Glkm
Transgene Detail

Summary

• Symbol: Tg(CD2-Tcra,-Tcrb)27Glkm
• Name: transgene insertion 27, Michael Glickman
• MGI ID: MGI:6469551
• Synonyms: C7 TCR Tg, ESAT-6-specific TCR Tg
• Transgene: Tg(CD2-Tcra,-Tcrb)27Glkm Location: unknown
• Alliance: Tg(CD2-Tcra,-Tcrb)27Glkm page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Tcra,-Tcrb)27Glkm expresses 3 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tardbp (MGI:2387629)
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: TCRalpha chain variable region (VJ) and beta chain variable region (VDJ) cDNAs are amplified from a secretory protein derived from M. tuberculosis. The ESAT-6_3-15 peptide-specific CD4+ T cell hybridoma clone 7 expresses TCR chains Vbeta10b-Dbeta1.1-Jbeta2.4 and Valpha11.2-Jalpha27. The complete TCR alpha and beta chains are excised and cloned into VA hCD2 cassette vectors which uses the human CD2 promoter to drive the expression of cDNAs in T cells. (J:141135)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:141135 Gallegos AM, et al., Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection. J Exp Med. 2008 Sep 29;205(10):2359-68
• All: 4 reference(s)