Crb1^em2Jnk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crb1^em2Jnk
• Name: crumbs family member 1, photoreceptor morphogenesis associated; endonuclease-mediated mutation 2, Jeremy N Kay
• MGI ID: MGI:6467932
• Synonyms: Crb1^delB
• Gene: Crb1 Location: Chr1:139124794-139304838 bp, - strand Genetic Position: Chr1, 60.87 cM
• Alliance: Crb1^em2Jnk page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL)F1

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1652 bp deletion from chr1:139,254,836-139,256,488, plus a deletion of two additional cytosines, deleting the entire first exon of the B isoform (Crb1-B) and the promoter region. This abolishes the B isoform while preserving other isoforms including the A isoform. (J:293375)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crb1 Mutation: 88 strains or lines available

References

• Original: J:293375 Ray TA, et al., Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease. Nat Commun. 2020 Jul 3;11(1):3328
• All: 1 reference(s)