Smoc2^tm1.2Knie
Targeted Allele Detail

Summary

• Symbol: Smoc2^tm1.2Knie
• Name: SPARC related modular calcium binding 2; targeted mutation 1.2, Karen Niederreither
• MGI ID: MGI:6467825
• Gene: Smoc2 Location: Chr17:14499768-14625052 bp, + strand Genetic Position: Chr17, 8.95 cM, cytoband A2
• Alliance: Smoc2^tm1.2Knie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296149
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a FRT-flanked selection maker and second loxP site were inserted downstream of exon 2. Flp-mediated recombination removed the selection marker leaving exon 2 floxed. Cre-mediated recombination deleted exon 2. (J:296149)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smoc2 Mutation: 20 strains or lines available

References

• Original: J:296149 Morkmued S, et al., Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss. Sci Rep. 2020 Sep 9;10(1):14817
• All: 1 reference(s)