Itln1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Itln1^em1Cya
• Name: intelectin 1 (galactofuranose binding); endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6467471
• Synonyms: Itln1^em1Cgen, omentin-1^-
• Gene: Itln1 Location: Chr1:171345690-171362862 bp, - strand Genetic Position: Chr1, 79.49 cM, cytoband H2
• Alliance: Itln1^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: TALEN target sites were designed in exon 4, and one base (A) was inserted into the sequence of the gene in one strand, causing a frameshift mutation and an early stop of encoded protein translation. Western blot analysis confirmed the absence of protein expression in the small intestine of homozygous mutant mice. (J:282124)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itln1 Mutation: 27 strains or lines available

References

• Original: J:282124 Rao SS, et al., Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines. Bone Res. 2018;6:9
• All: 3 reference(s)