Dnajc2^em2Adu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dnajc2^em2Adu
• Name: DnaJ heat shock protein family (Hsp40) member C2; endonuclease-mediated mutation 2, Amandine Duchesne
• MGI ID: MGI:6467410
• Gene: Dnajc2 Location: Chr5:21962279-21990183 bp, - strand Genetic Position: Chr5, 9.97 cM
• Alliance: Dnajc2^em2Adu page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1 bp deletion in the first common coding exon resulting in a frameshift and premature stop codon 99 bp downstream of the mutation. (J:291469)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnajc2 Mutation: 34 strains or lines available

References

• Original: J:291469 Helary L, et al., DNAJC2 is required for mouse early embryonic development. Biochem Biophys Res Commun. 2019 Aug 13;516(1):258-263
• All: 1 reference(s)