Itpr3^tm1Chen
Targeted Allele Detail

Summary

• Symbol: Itpr3^tm1Chen
• Name: inositol 1,4,5-triphosphate receptor 3; targeted mutation 1, Ju Chen
• MGI ID: MGI:6467333
• Synonyms: Itpr3^fl
• Gene: Itpr3 Location: Chr17:27276278-27341197 bp, + strand Genetic Position: Chr17, 13.68 cM
• Alliance: Itpr3^tm1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252084
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 3. (J:252084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itpr3 Mutation: 178 strains or lines available

References

• Original: J:252084 Ouyang K, et al., Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia. Nat Commun. 2014 Sep 12;5:4814
• All: 6 reference(s)