Pdcd1^{tm1(PDCD1)Smoc}
Targeted Allele Detail

Summary

• Symbol: Pdcd1^{tm1(PDCD1)Smoc}
• Name: programmed cell death 1; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6467254
• Synonyms: Pdcd1^em1(hPDCD1)
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^{tm1(PDCD1)Smoc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288057
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Pdcd1^{tm1(PDCD1)Smoc} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PDCD1 (5133)

  Pdcd1

  (MGI:104879)

• CRISPR-targeting replaced the mouse sequence with the human sequence. (J:288057)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 52 strains or lines available

References

• Original: J:288057 Zhu Y, et al., Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes Simplex Virus Type 2 Encoding an Antibody Against Programmed Cell Death 1. Mol Ther Oncolytics. 2019 Dec 20;15:201-213
• All: 1 reference(s)