Nlrc3^em2Tdk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nlrc3^em2Tdk
• Name: NLR family, CARD domain containing 3; endonuclease-mediated mutation 2, Thirumala-Devi Kanneganti
• MGI ID: MGI:6466744
• Synonyms: Nlrc3^ld
• Gene: Nlrc3 Location: Chr16:3762871-3794496 bp, - strand Genetic Position: Chr16, 2.32 cM
• Alliance: Nlrc3^em2Tdk page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 3.8 kb deletion containing exon 2 and 3. (J:240431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc3 Mutation: 53 strains or lines available

References

• Original: J:240431 Karki R, et al., NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016 Dec 12
• All: 3 reference(s)