Adamts17^tm1.1Taks
Targeted Allele Detail

Summary

• Symbol: Adamts17^tm1.1Taks
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 17; targeted mutation 1.1, Taku Saito
• MGI ID: MGI:6466716
• Synonyms: Adamts17^fl
• Gene: Adamts17 Location: Chr7:66489483-66802919 bp, + strand Genetic Position: Chr7, 36.26 cM
• Alliance: Adamts17^tm1.1Taks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295274
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4, and an FRT-flanked neomycin selection cassette and a second loxP site were inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette leaving exon 4 floxed. (J:295274)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adamts17 Mutation: 57 strains or lines available

References

• Original: J:295274 Oichi T, et al., Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway. Cell Mol Life Sci. 2019 Dec;76(23):4795-4809
• All: 1 reference(s)