Casp1^em1Tdk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Casp1^em1Tdk
• Name: caspase 1; endonuclease-mediated mutation 1, Thirumala-Devi Kanneganti
• MGI ID: MGI:6466671
• Synonyms: Casp1^Null
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^em1Tdk page

Mutation origin

• Strain of Origin: CD-1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of a ~3.8kb fragment containing exons 24. (J:263294)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 43 strains or lines available

References

• Original: J:263294 Man SM, et al., Differential roles of caspase-1 and caspase-11 in infection and inflammation. Sci Rep. 2017 Mar 27;7:45126
• All: 6 reference(s)