Sfxn3^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Sfxn3^m1Btlr
• Name: sideroflexin 3; mutation 1, Bruce Beutler
• MGI ID: MGI:6466664
• Synonyms: pew
• Gene: Sfxn3 Location: Chr19:45036015-45044822 bp, + strand Genetic Position: Chr19, 38.26 cM, cytoband D1
• Alliance: Sfxn3^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T-to-C transition resulting in a phenylalanine-to-serine substitution at amino acid 78 (F78S) of the protein (chromosome 19:45,049,815 bp).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfxn3 Mutation: 19 strains or lines available

References

• Original: J:289322 Chen B, et al., Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12931-12942
• All: 1 reference(s)