Pak3^{tm1b(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Pak3^{tm1b(EUCOMM)Hmgu}
• Name: p21 (RAC1) activated kinase 3; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6466592
• Gene: Pak3 Location: ChrX:142301587-142580792 bp, + strand Genetic Position: ChrX, 64.5 cM
• Alliance: Pak3^{tm1b(EUCOMM)Hmgu} page
• IMPC: Pak3 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292116
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Pak3^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon 2 leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:292116)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pak3 Mutation: 23 strains or lines available

References

• Original: J:292116 Castillon C, et al., The intellectual disability PAK3 R67C mutation impacts cognitive functions and adult hippocampal neurogenesis. Hum Mol Genet. 2020 Jul 29;29(12):1950-1968
• All: 1 reference(s)