Gpat3^em1Gliu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpat3^em1Gliu
• Name: glycerol-3-phosphate acyltransferase 3; endonuclease-mediated mutation 1, George Liu
• MGI ID: MGI:6466591
• Gene: Gpat3 Location: Chr5:100994095-101046968 bp, + strand Genetic Position: Chr5, 48.52 cM
• Alliance: Gpat3^em1Gliu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 620 bp deletion in the gene, including exon 2. (J:288248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpat3 Mutation: 22 strains or lines available

References

• Original: J:288248 Gao M, et al., GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Hum Mol Genet. 2020 Feb 1;29(3):432-443
• All: 1 reference(s)