P2ry6^em1Bdu
Endonuclease-mediated Allele Detail

Summary

• Symbol: P2ry6^em1Bdu
• Name: pyrimidinergic receptor P2Y, G-protein coupled, 6; endonuclease-mediated mutation 1, Bing Du
• MGI ID: MGI:6466531
• Synonyms: P2Y6^-
• Gene: P2ry6 Location: Chr7:100586837-100623856 bp, - strand Genetic Position: Chr7, 54.46 cM
• Alliance: P2ry6^em1Bdu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 genome editing technology was used to generate a deletion of 151 bases of the gene. (J:292395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry6 Mutation: 19 strains or lines available

References

• Original: J:292395 Li R, et al., Extracellular UDP and P2Y6 function as a danger signal to protect mice from vesicular stomatitis virus infection through an increase in IFN-beta production. J Immunol. 2014 Nov 1;193(9):4515-26
• All: 3 reference(s)