Tlr9^tm1Mjsk
Targeted Allele Detail

Summary

• Symbol: Tlr9^tm1Mjsk
• Name: toll-like receptor 9; targeted mutation 1, Mark J Shlomchik
• MGI ID: MGI:6460414
• Synonyms: TLR9flox
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^tm1Mjsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232440
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• The second exon, containing essentially all of the coding region, is flanked by loxP sites. (J:232440)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 63 strains or lines available

References

• Original: J:232440 Garcia-Martinez I, et al., Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9. J Clin Invest. 2016 Mar 1;126(3):859-64
• All: 15 reference(s)