Sting1^em1Zfa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sting1^em1Zfa
• Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1, Zusen Fan
• MGI ID: MGI:6459933
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^em1Zfa page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An 8 bp deletion (chr18:35735151-35735158; build GRCm38) was created using sgRNA 5-GGGACTTATAGAGGACCAGAAGG-3 with CRISPR/Cas9 technology. (J:282373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 45 strains or lines available

References

• Original: J:282373 Xia P, et al., The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat Immunol. 2018 Feb;19(2):141-150
• All: 1 reference(s)