Cnep1r1^em1Zfa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cnep1r1^em1Zfa
• Name: CTD nuclear envelope phosphatase 1 regulatory subunit 1; endonuclease-mediated mutation 1, Zusen Fan
• MGI ID: MGI:6459931
• Synonyms: Cnep1r1^fl
• Gene: Cnep1r1 Location: Chr8:88845397-88861738 bp, + strand Genetic Position: Chr8, 43.06 cM, cytoband C4
• Alliance: Cnep1r1^em1Zfa page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 2 and 3 using long-chain single-stranded oligodeoxynucleotides (lsODNs) and sgRNAs with CRISPR/Cas9 technology. LxoP sites were inserted at chr8:88125028-88125029 and chr8:88125950-88125951 (build GRCm38). (J:282373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnep1r1 Mutation: 16 strains or lines available

References

• Original: J:282373 Xia P, et al., The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat Immunol. 2018 Feb;19(2):141-150
• All: 1 reference(s)