Sting1^em1.1Dflr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sting1^em1.1Dflr
• Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 1.1, Deborah Fuller
• MGI ID: MGI:6458770
• Synonyms: Sting^fl
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^em1.1Dflr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 genome editing is used to introduce loxP sites surrounding exon 6. An FRT-flanked neomycin resistance (neo) cassette was also included in the floxed region, donwstream of exon 6. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:324485)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 51 strains or lines available

References

• Original: J:324485 Ulrich-Lewis JT, et al., STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses. Front Immunol. 2022;13:861710
• All: 2 reference(s)