Lrrc8e^em1Bcgen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc8e^em1Bcgen
• Name: leucine rich repeat containing 8 family, member E; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:6456566
• Gene: Lrrc8e Location: Chr8:4276827-4287470 bp, + strand Genetic Position: Chr8, 1.99 cM, cytoband A1.1
• Alliance: Lrrc8e^em1Bcgen page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• CRISPR-targeting generated a null allele. (J:288504)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc8e Mutation: 37 strains or lines available

References

• Original: J:288504 Zhou C, et al., Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19;52(5):767-781.e6
• All: 2 reference(s)