Tg(Myh6-Sgk1*S436D)1Anr
Transgene Detail

Summary

• Symbol: Tg(Myh6-Sgk1*S436D)1Anr
• Name: transgene insertion 1, Anthony Rosenzweig
• MGI ID: MGI:6456553
• Synonyms: SGK1-CA, Tg(Myh6-Sgk1*S422D)1Anr
• Transgene: Tg(Myh6-Sgk1*S436D)1Anr Location: unknown
• Alliance: Tg(Myh6-Sgk1*S436D)1Anr page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(Myh6-Sgk1*S436D)1Anr expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sgk1 (MGI:1340062)	modified mouse gene (S436D)

• Mutation details: The transgenic construct contains a hemagluttinin (HA) tagged mutant mouse Sgk1 sequence under the control of the cardiac-specific Myh6 promoter. The CA mutation replaces a serine at residue 436 (published as 422) for an aspartic acid (S436D), rendering the kinase constitutively active (CA). (J:210069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:210069 Das S, et al., Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation. 2012 Oct 30;126(18):2208-19
• All: 1 reference(s)