Diaph3^tm1.2Pji
Targeted Allele Detail

Summary

• Symbol: Diaph3^tm1.2Pji
• Name: diaphanous related formin 3; targeted mutation 1.2, Peng Ji
• MGI ID: MGI:6456062
• Gene: Diaph3 Location: Chr14:86892803-87378671 bp, - strand Genetic Position: Chr14, 43.95 cM, cytoband D3
• Alliance: Diaph3^tm1.2Pji page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT site, IRES, lacZ, loxP site, neomycin selection cassette, FRT site, and loxP site were inserted upstream of exon 10 and a third loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the lacZ and neomycin cassette and cre-mediated recombination deleted exons 10-11. (J:293763)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Diaph3 Mutation: 90 strains or lines available

References

• Original: J:293763 Mei Y, et al., Ineffective erythropoiesis caused by binucleated late-stage erythroblasts in mDia2 hematopoietic specific knockout mice. Haematologica. 2016 Jan;101(1):e1-5
• All: 3 reference(s)