Rubcn^tm1.1Jema
Targeted Allele Detail

Summary

• Symbol: Rubcn^tm1.1Jema
• Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein; targeted mutation 1.1, Jennifer Martinez
• MGI ID: MGI:6454089
• Synonyms: Rubcn^flox
• Gene: Rubcn Location: Chr16:32642072-32698121 bp, - strand Genetic Position: Chr16, 23.38 cM
• Alliance: Rubcn^tm1.1Jema page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293922
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT site flanked EUCOMM knockout first cassette (splice acceptor-LacZ/betagal-polyA + PGK-NeoR)and a loxP site were inserted into intron 5 and a second loxP site into intron 6. The lacZ and neo cassettes were removed through subsequent flp-mediated recombinatiom, leaving a conditional-ready allele with exon 6 floxed. (J:293922)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rubcn Mutation: 39 strains or lines available

References

• Original: J:293922 Sil P, et al., Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure. J Allergy Clin Immunol. 2020 May;145(5):1389-1405
• All: 3 reference(s)