Col1a1^{tm1(tetO-YFP/NKAP)Viss}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(tetO-YFP/NKAP)Viss}
• Name: collagen, type I, alpha 1; targeted mutation 1, Virginia Smith Shapiro
• MGI ID: MGI:6453870
• Synonyms: YFP-NKAP
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(tetO-YFP/NKAP)Viss} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274340
• Parent Cell Line: KH2 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Col1a1^{tm1(tetO-YFP/NKAP)Viss} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NKAP (79576)

  Nkap	(MGI:1914300)

  human gene

• Mutation details : Using RMCE (recombinase-mediated cassette exchange) with the Find Mice (IMSR):
  • Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
  • Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
  • Carrying any Col1a1 Mutation: 166 strains or lines available
• References:
  • Original: J:274340 Shapiro MJ, et al., NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival. J Immunol. 2019 Apr 15;202(8):2287-2295
  • All: 2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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