Tlr2^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tlr2^em1Gpt
• Name: toll-like receptor 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6452940
• Synonyms: Tlr2^em1Cd, Tlr2^em1Cd4034in1
• Gene: Tlr2 Location: Chr3:83743579-83749045 bp, - strand Genetic Position: Chr3, 37.4 cM
• Alliance: Tlr2^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3, which contains the entire coding region, was targeted using CRISPR/Cas9 technology, resulting in a 4033 bp shorter gene sequence (4034 bp deletion, 1 bp insertion). (J:292806)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr2 Mutation: 61 strains or lines available

References

• Original: J:292806 Miao G, et al., TLR2/CXCR4 coassociation facilitates Chlamydia pneumoniae infection-induced atherosclerosis. Am J Physiol Heart Circ Physiol. 2020 Jun 1;318(6):H1420-H1435
• All: 2 reference(s)