Ryr2^em2Wex
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ryr2^em2Wex
• Name: ryanodine receptor 2, cardiac; endonuclease-mediated mutation 2, Xander Wehrens
• MGI ID: MGI:6452596
• Synonyms: Ryr2^S2367D
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^em2Wex page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Targeting introduced the amino acid substitution of serine with aspartic acid at position 2367 (S2367D). (J:293263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 330 strains or lines available

References

• Original: J:293263 Campbell HM, et al., Loss of SPEG Inhibitory Phosphorylation of RyR2 Promotes Atrial Fibrillation. Circulation. 2020 Sep 22;142(12):1159-1172
• All: 1 reference(s)