Vangl2^tm2Pgrs
Targeted Allele Detail

Summary

• Symbol: Vangl2^tm2Pgrs
• Name: VANGL planar cell polarity 2; targeted mutation 2, Philippe Gros
• MGI ID: MGI:6452148
• Synonyms: Vangl2^fl
• Gene: Vangl2 Location: Chr1:171828527-171856011 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Vangl2^tm2Pgrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293073
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 3 and 4, creating a conditional-ready allele with exon 4 floxed. (J:293073)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vangl2 Mutation: 30 strains or lines available

References

• Original: J:293073 Rocque BL, et al., Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury. J Am Soc Nephrol. 2015 Mar;26(3):576-86
• All: 2 reference(s)