Srsf1^em1Iajc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Srsf1^em1Iajc
• Name: serine and arginine-rich splicing factor 1; endonuclease-mediated mutation 1, Javier Caceres and Ian Adams
• MGI ID: MGI:6452080
• Synonyms: Srsf1^NRS
• Gene: Srsf1 Location: Chr11:87938199-87944581 bp, + strand Genetic Position: Chr11, 52.4 cM
• Alliance: Srsf1^em1Iajc page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F2

Mutation description

• Allele Type: Endonuclease-mediated (Altered localization)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology knocked-in a nuclear retention sequence (NRS) in exon 4 of the main protein-coding isoform (Srsf1-205). (J:310422)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srsf1 Mutation: 26 strains or lines available

References

• Original: J:310422 Haward F, et al., Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function. Elife. 2021 Aug 2;10:e65104
• All: 1 reference(s)