Otop1^em1Lmn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Otop1^em1Lmn
• Name: otopetrin 1; endonuclease-mediated mutation 1, Emily Liman
• MGI ID: MGI:6452074
• Gene: Otop1 Location: Chr5:38434748-38461560 bp, + strand Genetic Position: Chr5, 20.35 cM
• Alliance: Otop1^em1Lmn page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas genome editing technology was used to generate a 38 nucleotide deletion of genomic sequences that encode the N-terminus of the protein. (J:293031)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otop1 Mutation: 38 strains or lines available

References

• Original: J:293031 Teng B, et al., Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1. Curr Biol. 2019 Nov 4;29(21):3647-3656.e5
• All: 1 reference(s)