Sema4d^tm1In
Targeted Allele Detail

Summary

• Symbol: Sema4d^tm1In
• Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; targeted mutation 1, Shinobu Inagaki
• MGI ID: MGI:6452073
• Gene: Sema4d Location: Chr13:51839565-51947783 bp, - strand Genetic Position: Chr13, 26.16 cM, cytoband B1
• Alliance: Sema4d^tm1In page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293022
• Parent Cell Line: EB3 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic region including the first exon encoding the initiation codon was replaced with a tau-lacZ construct and a neomycin-resistance cassette. (J:293022)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sema4d Mutation: 85 strains or lines available

References

• Original: J:293022 Taniguchi Y, et al., Sema4D deficiency results in an increase in the number of oligodendrocytes in healthy and injured mouse brains. J Neurosci Res. 2009 Oct;87(13):2833-41
• All: 6 reference(s)