Kdr^tm1.1Lcwe
Targeted Allele Detail

Summary

• Symbol: Kdr^tm1.1Lcwe
• Name: kinase insert domain protein receptor; targeted mutation 1.1, Lena Claeasson-Welsh
• MGI ID: MGI:6451820
• Synonyms: Vegfr2^Y949F
• Gene: Kdr Location: Chr5:76093487-76139118 bp, - strand Genetic Position: Chr5, 40.23 cM
• Alliance: Kdr^tm1.1Lcwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236742
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Velocigene technology was used to replace the tyrosine at position 949 to phenylalanine (Y949F) in exon 21 (TAC to TTC change). A loxP-flanked neomycin selection cassette was removed via cre-mediated recombination. (J:236742)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdr Mutation: 67 strains or lines available

References

• Original: J:236742 Li X, et al., VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nat Commun. 2016 Mar 23;7:11017
• All: 4 reference(s)