Megf8^tm1.1Nju
Targeted Allele Detail

Summary

• Symbol: Megf8^tm1.1Nju
• Name: multiple EGF-like-domains 8; targeted mutation 1.1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6451113
• Synonyms: Megf8^fl
• Gene: Megf8 Location: Chr7:25016589-25065342 bp, + strand Genetic Position: Chr7, 13.75 cM
• Alliance: Megf8^tm1.1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289436
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-SA-IRES-LacZneo-FRT cassette was inserted into intron 1 and exon 2-5 were flanked with two loxP sites. Flp-mediated recombination removed the reporter/selection cassette. (J:289436)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Megf8 Mutation: 97 strains or lines available

References

• Original: J:289436 Wang W, et al., Spatial and temporal deletion reveals a latent effect of Megf8 on the left-right patterning and heart development. Differentiation. 2020 May - Jun;113:19-25
• All: 1 reference(s)