Cfap65^em1Fzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cfap65^em1Fzh
• Name: cilia and flagella associated protein 65; endonuclease-mediated mutation 1, Feng Zhang
• MGI ID: MGI:6451090
• Gene: Cfap65 Location: Chr1:74941230-74974758 bp, - strand Genetic Position: Chr1, 38.54 cM
• Alliance: Cfap65^em1Fzh page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 2 bp deletion in the coding region resulting in a frameshift mutation (c.5060_5061delGG, p.Gly1687Alafs*4). (J:292578)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfap65 Mutation: 89 strains or lines available

References

• Original: J:292578 Li W, et al., Biallelic mutations in CFAP65 cause male infertility with multiple morphological abnormalities of the sperm flagella in humans and mice. J Med Genet. 2020 Feb;57(2):89-95
• All: 1 reference(s)