Tnfsf4^tm1.1Tjv
Targeted Allele Detail

Summary

• Symbol: Tnfsf4^tm1.1Tjv
• Name: tumor necrosis factor (ligand) superfamily, member 4; targeted mutation 1.1, Timothy J Vyse
• MGI ID: MGI:6450792
• Synonyms: OX40L^fl, Tnfsf4^fl
• Gene: Tnfsf4 Location: Chr1:161223009-161245777 bp, + strand Genetic Position: Chr1, 69.75 cM
• Alliance: Tnfsf4^tm1.1Tjv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275179
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neomycin resistance selection cassette followed by a second loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:275179)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf4 Mutation: 29 strains or lines available

References

• Original: J:275179 Cortini A, et al., B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis. Ann Rheum Dis. 2017 Dec;76(12):2095-2103
• All: 5 reference(s)