Il1a^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Il1a^tm1.1Itl
• Name: interleukin 1 alpha; targeted mutation 1.1, Ingenious Targeting Laboratory
• MGI ID: MGI:6450060
• Synonyms: IL-1alphaTM, R114Q
• Gene: Il1a Location: Chr2:129141530-129151892 bp, - strand Genetic Position: Chr2, 62.9 cM, cytoband F
• Alliance: Il1a^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283624
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: A point mutation was inserted into exon 5 such that codon 114 is altered from arginine to glutamine. An frt-flanked neomycin selection cassette was removed via Flp-mediated recombination. This mutation renders the encoded protein to be resistant to cleavage by thrombin. (J:283624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il1a Mutation: 30 strains or lines available

References

• Original: J:283624 Burzynski LC, et al., The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1alpha by Thrombin. Immunity. 2019 Apr 16;50(4):1033-1042.e6
• All: 2 reference(s)