Tlr7^tm1Spar
Targeted Allele Detail

Summary

• Symbol: Tlr7^tm1Spar
• Name: toll-like receptor 7; targeted mutation 1, Tim Sparwasser
• MGI ID: MGI:6449989
• Synonyms: Tlr7^fl, Tlr7^tm1Arte
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^tm1Spar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284385
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector consisted of one loxP site and FRT-flanked neomycin resistance cassette inserted upstream of exon 3 as well as a F3-flanked puromycin resistance cassette and one loxP site inserted downstream of exon 3. (J:284385)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 23 strains or lines available

References

• Original: J:284385 Solmaz G, et al., TLR7 Controls VSV Replication in CD169(+) SCS Macrophages and Associated Viral Neuroinvasion. Front Immunol. 2019;10:466
• All: 2 reference(s)