Klkb1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klkb1^em1Cya
• Name: kallikrein B, plasma 1; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6449097
• Synonyms: Klkb1^em1Cgen
• Gene: Klkb1 Location: Chr8:45719725-45747872 bp, - strand Genetic Position: Chr8, 25.17 cM, cytoband B1-B3
• Alliance: Klkb1^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The molecular lesion is a 1 base deletion (T, 248 of the ORF). This mutation caused a frameshift and an early stop after Leu100. The encoded protein was not detectable in plasma of homozygous mice. (J:291384)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klkb1 Mutation: 38 strains or lines available

References

• Original: J:291384 Wang B, et al., Plasma kallikrein contributes to ambient particulate matter-induced lung injury. Biochem Biophys Res Commun. 2019 Oct 20;518(3):409-415
• All: 1 reference(s)