Kcnk2^tm1.1Dabr
Targeted Allele Detail

Summary

• Symbol: Kcnk2^tm1.1Dabr
• Name: potassium channel, subfamily K, member 2; targeted mutation 1.1, Dennis Abraham
• MGI ID: MGI:6449060
• Synonyms: Kcnk2^fl
• Gene: Kcnk2 Location: Chr1:188940127-189134470 bp, - strand Genetic Position: Chr1, 94.22 cM
• Alliance: Kcnk2^tm1.1Dabr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292023
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 2, and a second loxP site followed by an FRT-flanked PGK-neo cassette just downstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:292023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnk2 Mutation: 35 strains or lines available

References

• Original: J:292023 Abraham DM, et al., The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction. J Clin Invest. 2018 Nov 1;128(11):4843-4855
• All: 1 reference(s)