Acvr1c^tm3Cfi
Targeted Allele Detail

Summary

• Symbol: Acvr1c^tm3Cfi
• Name: activin A receptor, type IC; targeted mutation 3, Carlos F Ibanez
• MGI ID: MGI:6448483
• Synonyms: Alk7^ASKA
• Gene: Acvr1c Location: Chr2:58157465-58247907 bp, - strand Genetic Position: Chr2, 33.05 cM
• Alliance: Acvr1c^tm3Cfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269067
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Two mutations, a leucine to valine change at amino acid 250 (p.L250V) in exon 4 and an a serine to glycine change at amino acid 270 (p.S270G) in exon 5 were introduced in the active site of the kinase. Substitution of the gatekeeper residue Ser270 with Gly creates an extra pocket in the active site, which is further expanded by mutating the adjacent residue Leu250 to Val. These mutations render the mutant receptor sensitive to inhibition by ATP competitive inhibitors, such as 2NaPP1. (J:269067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr1c Mutation: 39 strains or lines available

References

• Original: J:269067 Guo T, et al., Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife. 2014 Aug 25;3:e03245
• All: 1 reference(s)