Acvr1c^tm2.1Cfi
Targeted Allele Detail

Summary

• Symbol: Acvr1c^tm2.1Cfi
• Name: activin A receptor, type IC; targeted mutation 2.1, Carlos F Ibanez
• MGI ID: MGI:6448480
• Synonyms: Alk7^fx
• Gene: Acvr1c Location: Chr2:58157465-58247907 bp, - strand Genetic Position: Chr2, 33.05 cM
• Alliance: Acvr1c^tm2.1Cfi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269067
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin resistance gene were inserted upstream of exon 5 and a F3-site flanked puromycin resistance gene and a second loxP site were inserted downstream of exon 6. Flp-mediated recombination removed the selection cassettes leaving exons 5-6 floxed. (J:269067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr1c Mutation: 39 strains or lines available

References

• Original: J:269067 Guo T, et al., Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife. 2014 Aug 25;3:e03245
• All: 2 reference(s)