Havcr2^em1Chma
Endonuclease-mediated Allele Detail

Summary

• Symbol: Havcr2^em1Chma
• Name: hepatitis A virus cellular receptor 2; endonuclease-mediated mutation 1, Chunhong Ma
• MGI ID: MGI:6448363
• Gene: Havcr2 Location: Chr11:46345762-46372082 bp, + strand Genetic Position: Chr11, 27.9 cM
• Alliance: Havcr2^em1Chma page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• TALEN-targeting of exon 1 deleted two base pairs to produced a null allele. (J:262384)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Havcr2 Mutation: 30 strains or lines available

References

• Original: J:262384 Zhang H, et al., Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-kappaB/IL-6/STAT3 axis. Oncogene. 2018 May;37(18):2456-2468
• All: 2 reference(s)