Gt(ROSA)26Sor^{tm1.1(CMV-Rab7)Zmx}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CMV-Rab7)Zmx}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Zhenming Xu
• MGI ID: MGI:6448096
• Synonyms: Rosa26^{fl-STOP-fl-Rab7}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CMV-Rab7)Zmx} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285615
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(CMV-Rab7)Zmx} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rab7 (MGI:105068)

• Mutation details: A loxP-Stop-FRT-reverse neo-FRT-loxP-CMV promoter-Rab7 cDNA cassette was introduced to intron 1 of the mouse Gt(ROSA)26Sor gene. The Rab7 cDNA is full-length and derived from mouse. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:285615)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:285615 Yan H, et al., B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-kappaB Activation for Antibody Class-Switching. J Immunol. 2020 Mar 1;204(5):1146-1157
• All: 1 reference(s)